Kristin Gribble
ON THE RECORD · 10 verbatim quotes · every quote source-verified
“in transmitting information about maternal age from moms to offspring.”
Kristin Gribble · said date not stated · reported 2026-08-18
Gribble considers the possible role of mitochondrial DNA in passing maternal age information to offspring.
“There are likely gene variants out there that are protective of negative effects of advanced maternal age,”
Kristin Gribble · said date not stated · reported 2026-08-18
Gribble discusses how genetic variation may buffer against negative maternal age effects.
“Nearly all forms of life show some level of maternal age effect, and most are negative effects caused by advanced maternal age.”
Kristin Gribble · said date not stated · reported 2026-08-18
Gribble notes that most maternal age effects observed in life forms are negative.
“Selective pressure is much lower at advanced ages, particularly in rotifers, which are really geared to do most of their living and reproducing very young,”
Kristin Gribble · said date not stated · reported 2026-08-18
Gribble suggests weakened natural selection at older ages helps explain why maternal age effects persist.
“your health potentially depends on the health and environment of your mom and grandmother and great-grandmother.”
Kristin Gribble · said date not stated · reported 2026-08-18
Gribble says individual health may depend on the health and environment of previous maternal generations.
“In one of our strains, we saw that offspring from older mothers had a longer lifespan, implying a genetic mechanism may be involved in that beneficial effect.”
Kristin Gribble · said date not stated · reported 2026-08-18
Gribble cites a rotifer strain in which offspring of older mothers lived longer.
“Maternal age effects are incredibly common, from invertebrates up through humans, elephants, other primates and other mammals,”
Kristin Gribble · said date not stated · reported 2026-08-18
Gribble describes how widespread maternal age effects are across the animal kingdom.
“I want to know how it happens that information about a grandmother or great-grandmother's environment can affect the phenotype of her grandchild or great-grandchild,”
Kristin Gribble · said date not stated · reported 2026-08-18
Gribble describes what most excites her about the research on transgenerational information transfer.
“Understanding the mechanism in these simple invertebrates can help us understand how maternal age effects occur in people as well,”
Kristin Gribble · said date not stated · reported 2026-08-18
Gribble explains why her lab studies rotifers to understand maternal age effects in humans.
“It's not just about what's in your genome as an individual,”
Kristin Gribble · said date not stated · reported 2026-08-18
Gribble explains the implications of maternal age effects for human health and precision medicine.